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Infectious Diseases & Immunology Division

Scientists
   

Vision

Infectious diseases continue to be a serious health problem throughout the globe. The situation is further complicated by the emergence of drug resistant newer clones. Progress in controlling, eliminating or eradicating infectious diseases are a key part of the international health agenda. Keeping this in mind this Division of Indian Institute of Chemical Biology (IICB) is conducting various research programmes on Leishmania donovani, the causative agent for visceral leishmaniasis, and major enteropathogens like Vibrio cholerae and Shigella spp., which are major health concerns in India. With the use of genomics and proteomics the group at IICB has already undertaken intervention strategies for controlling the diseases caused by these human pathogens. The strategies include: 1) prevention of host-parasite interaction, 2) identifying new trans-membrane proteins, specific for the parasite that can be potential target sites for drug development, 3) targeting sub-cellular organelle, glycosome for anti-leishmanial drug design, 4) developing DNA topoisomerase-based therapeutic agents derived from indigenous plants, 5) structure-function relationship of important enzymes like DNA topoisomerase/adenosine kinase, 6) protein kinases in relation to cell signaling, 7) programmed cell death in Leishmania, 8) development of vaccines and diagnostics, 9) stress survival and regulation of virulence gene expression in V. cholerae, 10) role of diverse intra and extracellular small signaling molecules in expression of genes essential for growth, survival, biofilm formation and virulence of V. cholerae,11) genetic mapping of ctx, rrn and sxt loci of V. cholerae genome to understand rapid emergence of new epidemic clones 12) comparative genomics of Shigella species.
  

Objectives

  • Structural function of individual domains of type I and type II DNA topoisomerase of Leishmania donovani
  • DNA topoisomerases of L. donovani as targets for development of therapeutics
  • Programmed cell death of L. donovani induced by DNA topoisomerase inhibitors
  • Macrophage biology in relation to disease pathogenesis using visceral leishmaniasis as the model macrophage disease
  • Comprehensive cyclic nucleotide signaling in the infectivity of a eukaryotic intracellular pathogen like Leishmania
  • Immunomodulators of natural origin for effective therapy against macrophage-associated diseases
  • Regulation of protein kinase(s) and protein phosphatase(s) in Leishmania promastigotes
  • Storage, maintenance and characterization of Leishmania strains
  • Signaling mechanisms involving phosphatidyl choline hydrolysis to control interaction between macrophage and L. donovani
  • Studies on developmentally regulated galactosyltransferase, galactose terminal glycoconjugates and attenuation of L. donovani promastigotes
  • Search for new chemotherapeutic targets against Leishmania
  • Role of phospholipid composition on the adjuvanticity and protective efficacy of liposome-encapsulated L. donovani antigens
  • Development of a simple blood based assay for the diagnosis of visceral leismaniasis
  • Antigen presentation of experimental leishmaniasis
  • Immunoprophylaxis and immunotherapy against experimental leishmaniasis
  • Identification of host protective antigens of L. donovani
  • DNA vaccines against experimental visceral leishmaniasis
  • Hybrid cell vaccination against leishmaniasis
  • Modulation of immune response by dendritic cells
  • Regulation of anti-cancer activity with a ROS scavenger
  • Studies related to medicinal plants and their potentialities
  • Studies related to O-acetylated sialoglycoconjugates (Neu5,9Ac2-GPsALL) in childhood acute lymphoblastic leukemia
  • Understanding the impact of glycosylation of biomolecules in health and disease
  • Investigation on human C-reactive protein involved in various acute phase responses
  • Effect of hns mutation on colonizing efficiency of Vibrio cholerae
  • Studies related to stress survival and virulence gene expression in V. cholerae
  • Genome diversity and molecular basis of evolution of pathogenic clones of V. cholerae
  • Molecular basis of stringent response in V. cholerae
  • Comparative genomics of Shigella spp. to understand evolution of epidemic S. dysenteriae type 1 clone

Important P&I in the last 5 years

  • Biswas, A., Bhattacharya, A., Kar, S. and Das, P.K. (2011) Expression of IL-10-triggered STAT3-dependent IL-4Ra is required for induction of arginase 1 in visceral leishmaniasis. Eur. J. Immunol. (In press).
  • Kar, S., Sharma, G. and Das, P.K. (2011) Fucoidan cures infection against both antimony-susceptible and –resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants. J. Antimicrob. Chemother. [E-pub ahead of print].
  • Kar, S., Ukil, A. and Das, P.K. (2011) Cystatin cures visceral leishmaniasis by NF-kB-mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tp12-ERK pathway. Eur. J. Immunol. 41, 116-127.
  • Kar, S., Ukil, A., Sharma, G. and Das, P.K. (2010) MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. J. Leukocyte Biol. 88, 9-20. 
  • Bhattacharya, A., Biswas, A. and Das, P.K. Role of a differentially expressed cAMP phosphodiesterase in regulating the induction of resistance against oxidative damage in Leishmania donovani. Free Radical Biol. Med. 47: 1494-1506, 2009.
  • Kar, S., Ukil, A. and Das, P.K. Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kB and JAK/STAT pathways. Eur. J. Immunol. 39: 741-751, 2009.
  • Bhattacharya, A., Biswas, A. and Das, P.K. Role of intracellular cAMP in differentiation-coupled induction of resistance against oxidative damage in Leishmania donovani. Free Radical Biol. Med. 44: 779-794, 2008.
  • Mukherjee, S., Ukil, A. and Das, P.K. Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, using leishmaniasis as model macrophage disease. Antimicrob. Agents Chemother. 51: 1700-1707, 2007.
  • Das, B.B., Sen, A., Roy, A., Dasgupta, S.B., Ganguly, A., Mohanta, B.C., Dinda, B. and Majumder, H.K. Differential induction of Leishmania donovani bi-subunit toposiomerase I – DNA cleavage complex by selected flavones and camptothecin : Activity of flavones against camptothecin resistant topoisomerase I. Nucleic Acids Res. 34: 1121-1132, 2006.
  • M.C. Debnath, B.R.Sarkar, S.Ganguly and S Banerjee . Preparation of 99mTc –labeled conjugates of Ouabagenin and their biological evaluation in animal model. Nuclear Medicine Communications 27 : 271-279, 2006.
  • U.Roy. M Chatterjee Debnath, K Sanyal,  M.K.Das and S .Banerjee. Role of protecting groups in the preparation of thiolate complexes of Technetium -99m using cysteine as a model. J.of Labelled Compd. & Radiopharmaceuticals 49: 835-847, 2006.
  • Sen, N., Das, B. B., Ganguly, A., Banerjee, B., Sen, T., Majumder, H. K. Leishmania donovani: Intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. Exp. Parasitol. 114: 204-214, 2006.
  • Das, B. B., Sen, N, Dasgupta, S. B., Ganguly, A., Das, R. and Majumder, H. K. Topoisomerase research of kinetoplastid parasite Leishmania, with special reference to development of therapeutics. Indian J Med Res. 123: 221-232, 2006.
  • Sengupta, T., Mukherjee, M., Das, R., Das, A. and Majumder, H. K. Characterisation of the DNA-binding domain and identification of the active site residue in the ‘Gyr a’ half of Leishmania donovani topoisomerase II. Nucleic Acids Res. 33: 2364-2373, 2005.
  • Das, B.B., Sen, N., Dasgupta, S. B., Ganguly, A., Majumder, H. K. N-terminal region of the large subunit of Leishmania donovani bi-subunit topoisomerase I is involved in DNA relaxation and interaction with smaller subunit. J. Biol. Chem. 280: 16335-16344, 2005.
  • Manna, M., Majumder, H. K., Sundar, S., Bhaduri, A. N. The molecular characterization of clinical isolates from Indian Kala-azar patients by MLEE and RAPD-PCR. Med. Sci. Monit. 11: BR220-227, 2005.
  • Sengupta, T., Mukherjee, M., Das, A., Mandal, C., Das, R., Mukherjee, T. and Majumder, H.K. Characterisation of the ATPase activity of Toposiomerase II from L. donovani and identification of residues conferring resistance to etoposide. Biochem. J. 390: 419-426, 2005.
  • Karmakar, S., Ukil, A., Mukherjee, S. and Das, P.K. Regulation of guanylyl cyclase by intracellular Ca+2 in relation to the infectivity of the protozoan parasite, Leishmania donovani. Intl. J. Biochem. Cell Biol. 38: 1277-1289, 2006.
  • Maity, S., Ukil, A., Vedasiromoni, J.R. and Das, P.K. Biodistribution and pharmacokinetics of theaflavin-3,3’-digallate, the major antioxidant of black tea, in mice. Int. J. Pharmacol. 2: 240-246, 2006.
  • Ukil, A., Maity, S. and Das, P.K. Protection of experimental colitis by theaflavin-3,3¢-digallate correlates with inhibition of IKK and NF-kB activation. Brit. J. Pharmacol. 149: 121-131, 2006.
  • Ukil, A., Biswas, A., Das, T. and Das, P.K. 18b-Glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kB. J. Immunol. 175: 1161-1169, 2005.
  • Dey, R., Bhattacharya, J. and Datta, S.C. Calcium-dependent proteolytic activity of a cysteine protease caldonopain is detected during Leishmania infection. Mol. Cell Biochem. 281: 27-33, 2006.
  • Gupta, S., Raychaudhury, B., Banerjee, S., Das, B. and Datta, S.C. An intracellular calcium store is present in Leishmania donovani glycosomes. Exp. Parasitol. 113: 161-167, 2006.
  • Raychaudhury, B., Gupta, S., Banerjee, S. and Datta, S.C. Peroxisome is a reservoir of intracellular calcium. Biochim. Biophys. Acta 1760: 989-992, 2006.
  • Raychaudhury, B., Banerjee, S., Gupta, S., Singh, R.V. and Datta, S.C. Antiparasitic activity of a triphenyl tin complex against Leishmania donovani. Acta Tropica, 95: 1-8, 2005.
  • Chakraborty, P.D., Bhattacharya, D., Pal, S., and Ali, N. In vitro induction of nitric oxide by mouse peritoneal macrophages treated with human placental extract. Intl. Imm. Pharmacol. 6: 100-107, 2006.
  • Mazumdar, T., Anam, K., and Ali, N. Influence of phospholipid composition on the adjuvanticity and protective efficacy of liposome encapsulated Leishmania donovani antigens. J. Parasitol. 91: 269-274, 2005.
  • Saha, S., Mazumder, T., Anam, K., Ravindran, R., Bairagi, B., Saha, B., Goswami, R. P., Pramanik, N., Guha, S. K., Kar, S., Banerjee, D., and Ali, N. Leishmania promastigote membrane antigen based ELISA and immunoblotting for the differential diagnosis of Indian PKDL. J. Clinl. Microbiol. 43: 1269-77, 2005.
  • Ghosh, A., Paul K. and Chowdhury R. Role of H-NS in colonization, motility and bile dependent repression of virulence gene expression in Vibrio cholerae. Infect. Immun. 74: 3060-3064, 2006.
  • Banerjee S. and Chowdhury R. An orphan DNA (cytosine-5-)-methyltransferase in Vibrio cholerae. Microbiology 152: 1055-1062, 2006.
  • Bhattacharya T, Chatterjee S, Maiti D, Bhadra RK, Takeda Y, Nair GB, Nandy RK. Molecular analysis of the rstR and orfU genes of the CTX prophages integrated in the small chromosomes of environmental Vibrio cholerae non-O1, non-O139 strains. Environ. Microbiol. 8: 526-534, 2006.
  • Saha A, Deb R, Shah S, Ramamurthy T, Shinoda S, Mukhophadyay AK, Bhadra RK. PCR-based identification of Vibrio cholerae and the closely related species Vibrio mimicus using the large chromosomal ori sequence of Vibrio cholerae. FEMS Microbiol. Lett. 257: 84-91, 2006.
  • Kumai Y., Suzuki Y., Tanaka Y., Shima K., Bhadra R. K. Yamasaki Y., Kuroda K., Endo G. Characterization of multidrug-resistance phenotypes and genotypes of Escherichia coli strains isolated from swine from an abattoir in Osaka, Japan. Epidemiol. Infect. 133: 59-70, 2005.
  • Bandhyopadhyay, S., Chatterjee, M., Pal, S., Bonavali, S., Nair, C., Advani, S., Magrath, I. and Mandal, C. Antibodies against O-Acetylated sialic acids: A rapid, non-invasive screening method for monitoring of childhood acute lymphoblastic leukemia. Indian J. Biochem. Biophys. 43: 7-14, 2006.
  • Mukhopadhyay, Sumi (nee Bandyopadhyay) and Mandal, C. Glycobiology of Leishmania donovani. Indian J. Med. Res. 123: 203-220, 2006.
  • Sarkar, D., Dutta, A., Das, M., Sarkar, K., Mandal, C. and Chatterjee, M. Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian J. Pharmacol. 37: 371-375, 2005.
  • Bandyopadhyay, S., Mukherjee, K., Chatterjee, M., Bhattacharya, D.K. and Mandal. C. Development and evaluation of a DOT-ELISA to detect immune-complexed disease specific 9-O-acetylated sialoglycans in sera of pediatric acute lymphoblastic leukemia (ALL) patients. J. Immunol. Method. 297: 13-26, 2005.
  • Bandyopadhyay, S., Bhattacharyya, A., Sen, A.K., Das, T., Sa, G., Bhattacharya, D.K. and Mandal, C. Over expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia (ALL). Int. Immunol. 17: 177-191, 2005.
  • Ghosh, S., Bandyopadhyay, S., Pal, S., Das, B., Bhattacharya, D.K. and Mandal, C. Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of over expressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukemia. British J. Hematol. 128: 35-41, 2005.
  • Ghosh, S. Bandyopadhyay, S., Mullick, A., Pal, S., Vlasak, R., Bhattacharya, D.K. and Mandal, C. Interferon gamma promotes survival of lymphoblasts over-expressing 9-O-acetylated sialoglycoconjugates in childhood acute lymphoblastic leukemia (ALL). J. Cell. Biochem. 95: 206-216, 2005.
  • Ghosh, S., Bhattacharya, D. K. and Mandal, C. Altered erythrocyte membrane characteristics during anemia in childhood acute lymphoblastic leukemia. Ann. Hematol. 84: 76-84, 2005.
  • Dutta, A., Mandal, C. and Chatterjee, M. Development of a modified MTT assay for screening antimonial resistant field isolates of Indian visceral leishmaniasis. Parasitol. Int., 54: 119-122, 2005.
  • Singh, S.K., Sarkar, C., Mallick, S., Saha, B. and Bhadra, R. Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma. Pigment Cell Res. 18: 113-121, 2005.
  • Mallick, S., Singh, S.K., Sarkar, C., Saha, B. and Bhadra, R. Human placental lipid induces melanogenesis in B16/F10 cells by increasing the melanogenic protein tyrosinase in vitro. Pigment Cell Res. 18: 25-33, 2005.
  • Son, K.H., Pak, U.N., Sarkar, C. and Bhadra, R. A sensitive assay of red blood cell sorbitol level by high performance liquid chromatography: potential for diagnostic evaluation of diabetes. Clin. Chim. Acta. 354: 41-47, 2005.
  • Bera, R., Nayak, A., Sen, A.K., Chowdhury, B.P. and Bhadra, R. Isolation and characterization of the lipopolysaccharide from Acidiphilium strain GS18h/ATCC55963, a soil isolate of Indian copper mine. FEMS Microbiol. Lett. 246: 183-190, 2005.
  • Basu, R., Bhaumik, S., Basu, J.M., Naskar, K., De, T. And Roy, S. Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: Evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis. J. Immunol. 174: 7160-7171, 2005.
  • Chakraborty, D., Banerjee, S., Sen, A., Banerjee, K.K., Das, P. and Roy, S. Leishmania donovani affects antigen presentation of macrophage by disrupting lipid rafts. J. Immunol. 175: 3214-3224, 2005.
  • Theinert, S.M., Basu, R., Forgber, M., Roy, S., Sundar, S. and Walden, P. Identification of new antigens in visceral leishmaniasis by expression cloning and immunoblotting with sera of Kala-azar patients from Bihar, India. Infect. Immun. 73: 7018-7021, 2005.
  • Dey, R., Sarkar, A., Majumder, N., Bhattacharya (Majumdar), S., Roychoudhury, K., Bhattacharyya, S., Roy, S. and Majumdar, S. Regulation of impaired PKC signaling by chemokines in murine macrophages during visceral leishmaniasis. Infect. Immun. 73: 8334-8344, 2005.
  • Basu, M. K. Liposomal delivery of antileishmanial agents. J. Appl. Res. 5: 221-236, 2005.
  • Basu, M. K. and Ray, M. Macrophage and Leishmania: an unacceptable coexistence. Crit. Rev. Microbiol. 31: 1-10, 2005.
  • Das, B., Sen, N., Ganguly, A. and Majumder, H. K. Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani. FEBS Letts. 565: 81-88, 2004.
  • Sen, N., Das, B. B., Ganguly, A., Mukherjee, T., Tripathi, G., Bandyopadhyay, S. Rakshit, S., Sen, T., and Majumder, H. K. Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death and Differentiation, 11: 924-936, 2004.
  • Sen, N., Das, B. B., Ganguly, A., Mukherjee, T., Bandopadhyay, S., Majumder, H. K. Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani. J. Biol. Chem. 279: 52366-52375, 2004.
  • Das, A., Sengupta, T., Dasgupta, A and Majumder, H. K. Topoisomerases of kinetoplastid parasites as potential chemotherapeutic targets. Trends Parasitol. 20: 381-387, 2004.
  • Mukherjee, S., Das, L., Kole, L., Karmakar, S., Datta, N. and Das, P.K. Targeting of parasite-specific immunoliposome-encapsulated doxorubicin in the treatment of experimental visceral leishmaniasis. J. Infec. Dis. 189: 1024-1034, 2004.
  • Pandey, S., Chakraborti, P., Sharma, R., Bandyopadhyay, S., Sarkar, D., Adhya, S.. Involvement of Leishmania donovani major surface glycoprotein gp63 in promastigote multiplication. J. Biosci. 29: 15-22, 2004.
  • Sreenivas, G., Subba Raju, B.V., Singh, R., Selvapandiyan, A., Duncan, R., Sarkar, D., Nakhasi, H. L. and Salotra, P. DNA polymorphism assay distinguishes isolates of Leishmania donovani that causes kala-azar from those that cause post-kala-azar dermal leishmaniasis in humans. J. Clin. Microbiol. 42: 1739-1741, 2004.
  • Pal, S., Ghosh, S., Bandyopadhyay, S., Mandal, C. N., Bandhyopadhyay, S., Bhattacharya, D. K. and Mandal, C. Differential expression of 9-O-acetylated sialoglycoconjugates on leukemic blasts: a potential tool for long-term monitoring of children with acute lymphoblastic leukaemia Intl. J. Cancer 111: 270-277, 2004.
  • Pal, S., Bandhyopadhyay, S., Chatterjee, M., Hall, A. G., Bhattacharya, D. K. and Mandal, C. Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia. Clinic. Biochem. 37: 395-403, 2004.
  • Chava, A. K., Chatterjee, M., Sharma, V., Sundar, S. and Mandal, C. Differential expression of O-acetylated sialoglycoconjugates induces a variable degree of complement-mediated hemolysis in Indian leishmaniasis, J. Infect. Disease 189: 1257-1264, 2004.
  • Chava, A. K., Chatterjee, M., Gerwig, G. J., Kamerling, J. P. and Mandal, C. Identification of sialic acids on leishmania donovani amastigotes Biol. Chem 385: 59-66, 2004.
  • Bandyopadhyay, S., Chatterjee, M., Das, T., Bandyopadhyay, S., Sundar, S. and Mandal, C. Antibodies directed against O-acetylated sialoglycoconjugates accelerate complement activation in Leishmania donovani promastigotes. J. Infect disease, 190: 2010-2019, 2004.
  • Pal, S., Ghosh, S., Mandal, C.N., Brossmer, R., Schauer, R., Schwartz-Albiez, R. Bhattacharya, D.K. and Mandal, C. Purification and characterization of 9-O-acetylated sialoglycoproteins from leukaemic cells and their potential as immunological tool for monitoring childhood acute lymphoblastic leukaemia. Glycobiology 14: 859-870, 2004.
  • Das, T., Mandal, C.N. and Mandal, C. Protein A- a new ligand for human C-reactive protein. FEBS Lett., 576: 107-113, 2004.
  • Bandyopadhyay, S., Chatterjee, M., Pal, S., Waller, R. F., Sundar, S., McConville, M. and Mandal, C. Antibodies against O-acetylated sialoglycoconjugates; their purification, characterization and application as a novel probe for diagnosis and follow up of Indian Visceral Leishmaniasis patients Diagn. Microbiol. Infect. Dis. 50: 15-24, 2004.
  • Saha, B., Tonkal, A.M.D.J., Croft, S. and Roy, S. Mast cells at the host-protection versus immune evasion. Clin. Exp. Immunol. 137: 19-23, 2004.
  • Roy, K. C., Bandyopadhyay, G., Rakshit, S., Ray, M. and Bandyopadhyay, S. IL-4 alone without the involvement of GM-CSF transforms human peripheral blood monocytes to a CD1adim, CD83+ myeloid dendritic cell subset. J. Cell Sci. 117: 3435-3445, 2004.
  • Bandyopadhyay, G., Biswas, T., Roy, K.C., Mandal, S., Mandal, C., Pal, B. C., Bhattacharya, S., Rakshit, S., Bhattacharya, D.K., Chaudhuri, U., Konar, A. and Bandyopadhyay, S. Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Blood 104: 2514-2522, 2004.
  • Raychaudhury, B., Gupta, S., Banerjee, S., Das, B., and Datta, S. C. Isolation of Leishmania glycosomes by a rapid method. Anal. Biochem. 332: 404-408, 2004.
  • Pal, S., Ravindran, R., and Ali N. Combination therapy of established and chronic Leishmania donovani infection of BALB/c mice with sodium antimony gluconate in stearylamine-bearing liposomes. Antimicrob. Agents Chemother. 48: 3591-3593, 2004.
  • Ravindran, R., Anam, K., Bairagi, B. C., Saha, B., Pramanik, N., Guha, S. K., Goswami, R. P., Banerjee, D. and Ali, N. Characterization of immunoglobulin G and its subclass response to Indian kala-azar infection before and after chemotherapy. Infect. Immun. 72: 863-870, 2004.
  • Mazumder, T., Anam, K. and Ali, N. A mixed Th1/Th2 response elicited by liposomal formulation of Leishmania vaccine instructs Th1 responses and resistance to Leishmania donovani in susceptible BALB/c mice. Vaccine 22: 1162-1171, 2004.
  • Krishnan, H. H., Ghosh, A., Paul, K. and Chowdhury, R. Effect of anaerobiosis on expression of virulence factors in Vibrio cholerae. Infect. Immun. 72: 3961-3967, 2004.
  • Chatterjee, A., Chaudhuri, S., Saha G., Gupta S., and Chowdhury R.. Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae. J. Bacteriol. 188: 6809-6814, 2004.
  • Paul, K., Ghosh A., Sengupta N. and Chowdhury R. Competitive growth advantage of non-toxigenic mutants in the stationary phase in archival cultures of pathogenic Vibrio cholerae strains. Infect. Immun. 72: 5478-5482, 2004.
  • Saha, A., Haralalka, S. and Bhadra, R. K. A naturally occurring point mutation in the 13-mer R repeat affects the oriC function of the large chromosome of Vibrio cholerae O1 classical biotype. Arch. Microbiol. 182: 421-427, 2004.
  • K Bhowal, S Bhattacharyya, A Majumdar, C Giri, R Vannaja, N Ramamoorthy, S ganguly, S Banerjee & Mita Chatterjee Debnath. Technetium-99m DTPA dimethyl ester:A renal function imaging agent. Comparative studies in animals with Technetium_99m mercaptoacetyltriglycine and 131I-ortho-iodohippurate. Nuclear Medicine Communications 24 : 583-595, 2003.
  • Sengupta, T., Mukherjee, M., Mandal, C., Das, A., Majumder, H. K. Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani. Nucleic Acids Res. 31: 5305-16, 2003.
  • Chowdhury, A. R., Mandal, S., Goswami, A., Ghosh, M., Mandal, L., Chakraborty, D., Ganguly, A., Tripathi, G., Mukhopadhyay, S., Bandyopadhyay, S., Majumder, H. K. Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy. Mol. Med. 9: 26-36, 2003.
  • Karmakar, S., Bandyopadhyay, K., Biswas, A. and Das, P.K. Membrane orientation of laminin binding protein: An extracellular matrix bridging molecule of Leishmania donovani. Eur. J. Biochem. 270: 1-8, 2003.
  • Datta, N., Mukherjee, S., Das, L. and Das, P.K. Targeting of immunostimulatory DNA cures experimental visceral leishmaniasis through nitric oxide upregulation and T cell activation. Eur. J. Immunol. 33: 1508-1518, 2003.
  • Ukil, A., Maity, S., Karmakar, S., Datta, N. and Das, P.K. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulfonic acid-induced colitis. Br. J. Pharmacol. 139: 209-218, 2003.
  • Karmakar, S., Bandyopadhyay, K., Biswas, A. and Das, P.K. Membrane orientation of laminin binding protein. Eur. J. Biochem. 270: 3806-3813, 2003.
  • Maity, S., Ukil, A., Karmakar, S., Datta, N., Chaudhuri, T., Vedasiromoni, J. R., Ganguly, D. K. and Das, P. K. Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis. Eur. J. Pharmacol. 470: 103-112, 2003.
  • Das, T., Sen, A., Kempft, Pramanik S.R., Mandal, C.N. and Mandal, C. Induction of Glycosylation in Human C-Reactive Protein under Different Pathological Conditions. Biochem. J. 373: 1-11, 2003.
  • Chatterjee, M., Chava, K., Kohla, G., Pal, S., Merling, S., Hinderlich, U., Unger, P., Strasser, G.J., Gerwig, J.P., Kamerling, R., Vlasak, P.R., Crocker, R., Schauer, R., Albiez, S. and Mandal, C. Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes. Glycobiology 13: 351-361, 2003.

  • Dasgupta, B., Roychoudhury, K., Ganguly, S., Akbar, M.A., Das, P. and Roy, S. Infection of human mononuclear phagocytes and macrophage-like THP1 cells with Leishmania donovani results in modulation of expression of a subset of chemokines and a chemokine receptor. Scand. J. Immunol. 57: 366-374, 2003.
  • Ghosh, M., Pal, C., Ray, M., Maitra, S., Mandal, L. and Bandyopadhyay, S. Dendritic cell-based immunotherapy combined with antimony-based chemotherapy cures established murive visceral leishmaniasis. J. Immunol. 170: 5625-5629, 2003.
  • Dasgupta, B., Roychoudhury, K., Ganguly, S., Sinha, P. K., Vimal, S., Das, P. and Roy, S. Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells. Ann. Trop. Med. Parasitol. 97: 245-257, 2003.
  • Nandi, S., Maiti, D., Saha, A. and Bhadra, R.K. Genesis of variants of Vibrio cholerae O1 biotype El Tor: role of the CTXF array and its position in the genome. Microbiology 149: 89-97, 2003.
  • Sengupta, N., Pal, K., and Chowdhury, R. The global regulator ArcA modulates expression of virulence factors in Vibrio cholerae. Infect. Immun. 71: 5583-5589, 2003.
  • Haralalka, S., Nandi, S., Bhadra, R. K. Mutation in the relA gene of Vibrio cholerae affects in vitro and in vivo expression of virulence factors. J. Bacteriol. 185: 4672-4682, 2003.
  • Datta, P.P and Bhadra, R.K. Cold shock response and major cold shock proteins of Vibrio cholerae. Appl. Environ. Microbiol. 69: 6361-6369, 2003.
  • Das, A., Mandal, C., Dasgupta, A., Sengupta, T., Majumder, H. K. An insight into the active site of a type I DNA topoisomerase from the kinetoplastid protozoan Leishmania donovani. Nucleic Acids Res. 30:794-802, 2002.
  • Bandyopadhyay, K., Karmakar, S., Ghosh, A., Das, P. K. High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences. Eur. J. Biochem. 269:1622-1629, 2002.
  • Roy Chowdhury, A., Sharma, S., Mandal, S., Goswami, A., Mukhopadhyay, S. and Majumder, H.K. Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem. J. 366: 653- 660, 2002.
  • Afrin, F., Rajesh, R., Anam, K., Gopinath, M., Pal, S. and Ali, N. Characteization of Leishmania donovani antigens encapsulated in liposomes that induce protective immunity in BALB/c mice. Infect. Immun. 70: 6697-6706, 2002.
  • Bhattacharya, S., Ghosh, S., Dasgupta, B., Mazumdar, D., Roy, S., Majumdar, S. Chemokine - induced Leishmanicidal activity in murine macrophage via the generation of nitric oxide. J. Infect. Dis. 185: 1704-1708, 2002.
  • Ghosh, S., Bhattacharya, S., Sirkar, M., Saha, G.S., Das, T., Majumdar, D., Roy, S. and Majumdar S. Leishmania donovani suppresses activated protein 1 and NF-kB activation in host macrophages via ceramide generation: involvement of extra cellular signal-regulated kinase. Infect. Immun. 70: 6828-6838, 2002.
  • Chava, K., Chatterjee, M., Sundar, S. and Mandal, C. Development of an assay for quantification of linkage-specific O-acetylated sialoglycans on erythrocytes; its application in indian visceral leishmnaiasis J. Immunol. Methods 270: 1-10, 2002.
  • Paul, I., Mandal, C., Allen, A.K. and Mandal, C. Molecular variants of C-reactive proteins from the major carp Catla catla in fresh and polluted aquatic environments. Glycoconjugate J. 18: 547-556, 2002.
  • Pal, S., Chatterjee, M., Bhattacharya, D.K., Bandhyopadhyay, S., Mandal, C.N. and Mandal, C. O-acetyl sialic acid specific IgM as a diagnostic marker in childhood acute lymphoblastic leukaemia. Glycoconjugate J. 18: 529-537, 2002.
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