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Scientists
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Vision
To conduct
well-targeted basic research for improving health and quality of life,
as also for promoting future economic growth through innovation in
biotechnology, driven by multi-disciplinary approach.
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Objectives
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This group is
involved in both basic and applied biological research covering various
topics within the areas of health, agriculture and process
biotechnology. The main research focus is to promote development of new
products, processes and technologies of commercial and industrial
importance through application of basic biological research. The field
of research activities includes investigation on:
- medicinal plants
for anti-neoplastic, anti-ulcer, hepatoprotective, anti-inflammatory,
antioxidant and anti-leishmania agents;
- isolation of
lead bioactive compounds from plant, microbe, animal or venom for
useful pharmacological activity;
- establishing the
mechanism of gastric ulceration; tissue targeted drug delivery;
- innovative and
faster immunodiagnostic techniques to estimate mycotoxin contaminants
from food stuffs;
- bioefficacy and
analytical evaluation of herbal medicines;
- biochemistry of
mushroom sporulation;
- yeast trehalose
metabolism and enzyme/ protein repairing;
- regulatory
mechanisms for production and secretion of glycosidase enzymes for
biotechnological applications and
- plant gene
manipulation for improved production of pharmaceutical/nutraceuticals.
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Important
Publication in the last 5 years:
- Ghosh, P.,
Besra, S.E., Tripathi, G., Mitra, S. and Vedasiromoni, J. R. Cytotoxic
and apoptogenic effect of tea (Camellia sinensis var. assamica) root
extract (TRE) and two of its steroidal saponins TS1 and TS2 on human
leukemic cell lines K562 and U937 and on cells of CML and ALL patients.
Leuk Res. 2006; 30 (4): 459-68.
- Chattopadhyay,
P., Besra, S. E., Gomes, A., Das, M., Sur, P., Mitra, S. and
Vedasiromoni, J. R. Anti-inflammatory activity of tea (Camellia
sinensis) root extract. Life Sci. 2004; 74 (15): 1839-49.
- Pal A and Dhar
T. K. An analytical device for on-site immunoassay. Demonstration of
its applicability in semiquantitative detection of aflatoxin B1
in a batch of samples with ultrahigh sensitivity. Anal. Chem.
2004; 76 (1): 98-104.
- Pal A., Acharya
D., Saha D. and Dhar T. K. Development of a membrane-based
immunofiltration assay for the detection of T-2 toxin. Anal. Chem.
2004; 76 (14): 4237-40.
- Swarnakar, S.,
Ganguly, K., Kundu, P., Banerjee, A., Maity, P. and Sharma, A.V.
Curcumin regulates expression and activity of matrix metalloproteinases
-9 and -2 during prevention and healing of indomethacin- induced
gastric ulcer. J. Biol. Chem. 2005, 280: 9409-15.
- Ganguly, K.,
Kundu, P., Banerjee, A., Reiter, R.J. and Swarnakar, S. Hydrogen
peroxide-mediated downregulation of matrix metalloprotease-2 in
indomethacin-induced gastric ulceration is blocked by melatonin and
other antioxidants. Free. Radical Biol. Med. 2006 (in press).
- Chakraborty, T.
K., Basu, D., Das, N., Sengupta, S. and Mukherjee, M. The mannitol
cycle in Pleurotus ostreatus (Florida). FEMS Microbiol. Lett.
2004, 236: 307-311.
- Mukherjee, S.,
Basak, S. and Khowala, S. Regulation (Alteration) of activity and
conformation of sucrase on co-aggregation with cellobiase in culture
medium of Termitomyces clypeatus. Biotechnology Progress.
2002, 18: 404-408.
- Sarkar, S. and
Das, N. Mannosylated liposomal flavonoid in combating age-related
ischemia-repurfusion induced oxidative damage in rat brain. Mech.
Ageing Development 2006,127: 391-397.
- Mandal, A. K.,
Basu, M. K., Chakraborty, R. N. and Das, N. Hepatoprotective activity
of liposomal flavonoid against arsenite induced liver fibrosis. Toxicology,
2006 (in press).
- Extracellular
trehalose utilization by Saccharomyces cerevisiae. Basu, A.,
Bhattacharyya, S., Chaudhuri, P., Sengupta, S. and Ghosh, A. K. Biochem.
Biophsica Acta 2006, 1760: 134 - 140.
- Kumar, A. and
Chattopadhyay, S. DNA damage protecting activity and antioxidant
potential of pudina extract. Food Chemistry 2006 (in press).
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