Scientists
Vision
This division deals with systems and cell biology, investigating subcellular organelles and intracellular signaling events in normal physiology and in disease. Major interests are in the area of neurological diseases, reproductive physiology and control of reproduction, cardiac hypertrophy, diabetes and some metabolic and parasitic diseases.
Objectives
Under the section of neurological disorders, there are a number of projects that look into the structure and function of developing astrocytes with a view to study the mechanism of action of intrinsic regulators in the plasticity of astroglial cells, to understand the basis of narcotic addiction towards anti-addictive drug development, molecular basis of neurodegeneration and development of strategies for neuroprotection, and stem cells in corneal implantation and in neurodegenerative diseases.
Mechanisms of cardiac dysfunction by thyroid hormone and glucocorticoid are investigated in the Endocrinology section. In addition to these, molecular mechanism of insulin resistance and defect in insulin signaling in diabetes type 2, genetic basis of hypothyroid induced reproductive disorders with emphasis on the role of lysyl hydroxylases, MMPs and TIMPs and the role of homeodomain transcription factor in ovarian function and its development are investigated.
Under the reproductive biology section, biochemical basis of sperm motility and its function activities, elucidation of pathophysiologic mechanisms underlying reproductive malfunctions and development of a conceptual "over the counter" contraceptive modality with anti-HIV hallmark are investigated.
The causes, manifestation and management of anemia during visceral leishmaniasis, studies on host-pathogen interaction and genetics of human polyomavirus JCV and BKV natural isolates as well as the metagenomic analysis of microbial population, particularly extreamophiles from metal rich environments are also investigated in this division.
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Important P&I in the last 5 years
- A. Dasgupta, S Das and P K Sarkar (2005) Thyroid hormone stimulates g-glutamyl transpeptidase in the developing rat cerebra and in astroglial cultures. J. Neurosci. Res. 82, 851-857.
- A. Joardar, A. K. Sen and Sumantra Das (2006) Docosahexaenoic acid facilitates cell maturation and beta adrenergic transmission in astrocytes. J. Lipid Res. 47, 571-581.
- De K, Ghosh G, Datta M, Konar A, Bandyopadhyay J, Bandyopadhyay D, Bhattacharya, S and Bandyopadhyay A. (2004) Analysis of Differentially Expressed Genes in Hyperthyroid-Induced Hypertrophied Heart by cDNA Microarray. J. Endocrinol. 182, 304-314.
- Banerjee S., Dungdung S.R., Das K. & Majumder G.C.: Synchronous modulation of cell-surface lectin and its receptor in a homologous cell population: a novel mechanism of cellular regulation. Exp. Cell. Res. 312, 2299-2308, (2006).
- Bandyopadhyay S, Chakrabarty J, Banerjee S, Pal AK, Goswami SK, Chakravarty BN, Kabir SN. (2004) Primordial germ cell migration in the rat: preliminary evidence for a role of galactosyltransferase. Biol. Reprod. 71:1822-1827.
- Goswami SK, Das T, Chattopadhyay R, Sawhney V, Chaudhury K, Chakravarty BN, Kabir SN (2004) A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. Hum Reprod. 19:2031-2035.
- Saha Roy, S., Sen, G., Biswas, T. (2005) Role of sulfhydryl groups in band 3 in the inhibition of phosphate transport across erythrocyte membrane in visceral leishmaniasis. Arch. Biochem. Biophys. 436, 121-127.
- Sen, G., Mandal,, S., Saha Roy, S., Mukhopadhayay, S., Biswas, T. (2005) Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis. Free Rad. Biol. Med. 38, 1257-1264.
- S Bhattacharjee and Chakraborty , T. (2004) High Reactivation of BK Virus Variants in Asian Indians with renal Disorders and During Pregnancy, Virus Genes, 28, 157-168.
- Saravanan KS., Sindhu KM., Senthil Kumar KS and Mohanakumar KP. (2006). L-Deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats. Neurochem. Intl. 49; 28-40.
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