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Cancer & Cell Biology

 

Scientists

 

 

Vision

This division has recently been created by bringing together six dedicated scientists and more than 50 research scholars with expertise in a broad range of cancer-related fields. Our long term goals are to focus on the comprehensive understanding of cancer at many levels ranging from the investigation of molecular and genetic basis of cancer, the elucidation of cellular processes altered during development of cancers, immune response and inflammation. The faculties conduct both basic and translational research on a range of topics that include lung, brain, oral, breast, pancreatic and cervical cancers and leukemias etc. Our current focus is on identification of pure herbal and/or synthetic compounds/herbal extracts having in-vitro anti-proliferative activities against different cancer cell lines, understanding alterations and cross-talks among signalling pathways in cancers. Emphasis is also given on characterization of novel targets, identification of target-specific leads and biologics using systems biology approaches. Optimization of lead molecules by development of in-silico library of compounds through pharmacophore modeling and structure-based drug design, drug delivery, in vivo efficacy, pharmacokinetics and in-vivo toxicity/safety pharmacology are a few current activities of the division. Research on cancer stem cells is ongoing.  Development of animal models of tumor is our major future goal to study signaling crosstalk in vivo. The collaboration with Medicinal Chemistry, Bioinformatics, in-silico modeling groups and interaction with clinicians make this division a rapidly growing unit with a unique goal to deliver low cost affordable healthcare by providing novel diagnostics and therapeutics in cancers.

 

Research Summary

Dr.Chitra Mandal

  • Role of sialic acid modulator enzymes in leukemia and pancreatic cancer.
  • Glycoproteomics of leukemia-associated sialoglycans and their functional role
  • Development of the high efficacy anti-cancer agent from the natural sources on the basis of the knowledge of existing structure.
  • Checking the efficacy of herbal compounds combination with existing toxic anti-cancer drugs.
  • Synthetically modification of herbal compound for identification of main functional group(s) and interaction with DNA through biophysical and in silico approaches.
  • Cellular signal networking modulation of two identified potential herbal compounds for target protein identification through in vitro, proteomics and in silico approaches.
  • G1/S and G2/M regulation and role of novel herbal compound in glioma and pancreatic cancer.

Dr.Santu Bandyopadhyay

  • Evaluation of differential sensitivity of cancer cells vs. normal cells to ROS-inducing natural products with mechanisms of action.
  • Redox regulation of cancer cell apoptosis.
  • Reversal of drug-resistance by redox manipulation

Dr.Susanta Roychowdhury

  • Deciphering the mechanism of chromosomal instability in human cancer.
  • Deciphering the mechanism of chemo-resistance in human cancer.
  • Identification of susceptibility alleles for the development of oral cancer.
  • Understanding of cause and consequences of mitotic abnormality in human cancer.

Dr. Padma Das

  • Isolate, identify, characterize and evaluate the biological effects of the compounds extracted from mycelia and/or fruit bodies of edible mushrooms and Sesbania grandiflora flower extract etc.
  • Understanding the mechanism of Andrographolide analogue mediated apoptosis in human leukemic cells.

Dr. Mrinal K. Ghosh

  • Understand the cross-regulation of Wnt/β-catenin and EGFR signalling.
  • Role and regulation of ubiquitin ligases & deubiquitinases in post-translational modifications of crucial proteins like c-Myc, PTEN & pRb.
  • Involvement (mode & mechanism) of DEAD Box RNA Helicase (p68).
  • Development of in vivo Animal Models of Tumor and Study of Signaling Crosstalk.
  • Exploration of Aberrations in Cancer Stem Cell Signaling.
  • Development of More Effective Prognostics and Therapeutics Against Brain Cancer

Dr. Malini Sen

  • Evaluating the role of Wnt Signaling in Immune response and Inflammation.
  • Evaluating the role of WISP3 (Wnt induced secreted protein 3) in the regulation of cellular hypertrophy and oxidative stress.
  • Investigating means for inhibition of inflammation and oxidative stress upon detailed analysis of appropriate signal transduction pathways.

Dr. Krishna Das Saha

  • Role and characterization of Leishmanial integral membrane proteins and sphingolipids in cancer
  • Anti-inflammatory role in arthritis and other inflammatory diseases.

Recent Publications

  1. Mondal S, Bandyopadhyay S, Ghosh MK, Mukhopadhyay S, Roy S and Mandal C. Natural Products: Promising Resources For Cancer Drug Discovery. Anticancer Agents Med Chem. 2011 Jun 27. [Epub ahead of print]
  2. Mandal C, Mandal CN, Chandra S, Schauer R and Mandal C. Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia. Glycobiology. 2011 Aug 4. [Epub ahead of print]
  3. Mandal C, Roychoudhury S, Roy S. (2011) Cancer research: India meets the West. Cell Death and Differentiation. Jun 17. doi: 10.1038/cdd.2011.85. [Epub ahead of print].
  4. Mukherjee K, Chowdhury S, Mondal S, Mandal C, Chandra S and Mandal C. 9-O-Acetyl GD3 in Lymphoid and Erythroid Cells. Adv Exp Med Biol. 2011;705:317-334.
  5. Bhattacharya K, Samanta SK, Tripathi R, Mallick A, Chandra S, Pal BC, Shaha C and Mandal C. Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol. 2010, 79(3):361-72.
  6. Mandal C, Tringali C, Mondal S, Anastasia L, Chandra S, Venerando B, Mandal C.Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells. Int J Cancer. 2010 Jan 15;126(2):337-49.
  7. Mondal S, Mandal C, Sangwan R, Chandra S, Mandal C. Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol Cancer. 2010 Sep 13;9:239.
  8. Mondal S, Chandra S, Mandal C. Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia. Leuk Res. 2010 Apr;34(4):463-70. Epub 2009 Aug 25.
  9. Chowdhury R, Chowdhury S, Roychoudhury P, Mandal C, Chaudhuri K. Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation. Apoptosis. 2009 Jan;14(1):108-23.
  10. Pal A, Bhattacharya I, Bhattacharya K, Mandal C, Ray M. Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in sarcoma-180 bearing mice: involvement of MAP kinase, NF-kappa beta signal transduction pathway. Mol Immunol. 2009 Jun;46(10):2039-44. Epub 2009 Apr 17.
  11. Wagh V, Chile S, Monahar S, Pal BC, Bandyopadhyay S, Sharma S, Joshi K. NPB001-05 inhibits Bcr-Abl kinase leading to apoptosis of imatinib-resistant cells. Front Biosci (Elite Ed). 2011 Jun 1;3:1273-88.
  12. Rakshit S, Mandal L, Pal BC, Bagchi J, Biswas N, Chaudhuri J, Chowdhury AA, Manna A, Chaudhuri U, Konar A, Mukherjee T, Jaisankar P, Bandyopadhyay S. Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells. Biochem Pharmacol. 2010 Dec 1;80(11):1662-75. Epub 2010 Sep 9.
  13. Manna PP, Chakrabarti G, Bandyopadhyay S. Innate immune defense in visceral leishmaniasis: cytokine mediated protective role by allogeneic effector cell. Vaccine. 2010 Jan 8;28(3):803-10. Epub 2009 Oct 29.
  14. Rakshit S, Bagchi J, Mandal L, Paul K, Ganguly D, Bhattacharjee S, Ghosh M, Biswas N, Chaudhuri U, Bandyopadhyay S. N-acetyl cysteine enhances imatinib-induced apoptosis of Bcr-Abl+ cells by endothelial nitric oxide synthase-mediated production of nitric oxide. Apoptosis. 2009 Mar;14(3):298-308.
  15. Nath S, Banerjee T, Sen D, Das T, Roychoudhury S. Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10. J Biol Chem. 2011 May 6;286(18):15666-77. Epub 2011 Mar 15.
  16. Datta De D, Bhattacharjya S, Maitra M, Datta A, Choudhury A, Dhali GK, Roychoudhury S. IL1B induced Smad 7 negatively regulates gastrin expression.PLoS One. 2011 Mar 22;6(3):e14775.
  17. Ghosh S, Ghosh A, Maiti GP, Mukherjee N, Dutta S, Roy A, Roychoudhury S, Panda CK. LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications. Mol Cancer. 2010 Mar 12;9:58.
  18. Mitra S, Mazumder Indra D, Bhattacharya N, Singh RK, Basu PS, Mondal RK, Roy A, Zabarovsky ER, Roychoudhury S, Panda CK. RBSP3 is frequently altered in premalignant cervical lesions: clinical and prognostic significance. Genes Chromosomes Cancer. 2010 Feb;49(2):155-70.
  19. Banerjee T, Nath S, Roychoudhury S. DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling. Nucleic Acids Res. 2009 May;37(8):2688-98. Epub 2009 Mar 9.
  20. Chakravorty M, Datta De D, Choudhury A, Roychoudhury S. IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int J Biochem Cell Biol. 2009 Jul;41(7):1502-10. Epub 2009 Jan 8.
  21. Misra C, Majumder M, Bajaj S, Ghosh S, Roy B, Roychoudhury S. Polymorphisms at p53, p73, and MDM2 loci modulate the risk of tobacco associated leukoplakia and oral cancer. Mol Carcinog. 2009 Sep;48(9):790-800.
  22. Klug SJ, Ressing M, Koenig J, Abba MC, Agorastos T, Brenna SM, Ciotti M, Das BR, Del Mistro A, Dybikowska A, Giuliano AR, Gudleviciene Z, Gyllensten U, Haws AL, Helland A, Herrington CS, Hildesheim A, Humbey O, Jee SH, Kim JW, Madeleine MM, Menczer J, Ngan HY, Nishikawa A, Niwa Y, Pegoraro R, Pillai MR, Ranzani G, Rezza G, Rosenthal AN, Roychoudhury S, Saranath D, Schmitt VM, Sengupta S, Settheetham-Ishida W, Shirasawa H, Snijders PJ, Stoler MH, Suárez-Rincón AE, Szarka K, Tachezy R, Ueda M, van der Zee AG, von Knebel Doeberitz M, Wu MT, Yamashita T, Zehbe I, Blettner M. TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncol. 2009 Aug;10(8):772-84. Epub 2009 Jul 20.
  23. Sen M, Ghosh G. Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts. J Immunol. 2008 Oct 1;181(7):4441-5.
  24. Saha P, Sen R, Hariharan C, Kumar D, Das P, Chatterjee M. Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes. Free Radic Res. 2009;43(11):1101-10.
  25. Das B, Chowdhury C, Kumar D, Sen R, Roy R, Das P, Chatterjee M. Synthesis, cytotoxicity, and structure-activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6947-50. Epub 2010 Oct 23.
  26. Sarkar A, Saha P, Mandal G, Mukhopadhyay D, Roy S, Singh SK, Das S, Goswami RP, Saha B, Kumar D, Das P, Chatterjee M. Monitoring of intracellular nitric oxide in leishmaniasis: its applicability in patients with visceral leishmaniasis. Cytometry A. 2011 Jan;79(1):35-45.
  27. Mandal M, Kumar D, Roy R, Sen R, Das P, Chatterjee M, Jaisankar P. Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity. Bioorg Med Chem Lett. 2011 May 15;21(10):3084-7. Epub 2011 Mar 16.

 
Uploaded on 16th August'2011

 

 
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